参考文献

[1]杜克斯，李泽巧，张宝江，等.面部皮肤衰老的外观变化及形成因素[J].日用化学工业，2022，52（2）:199-206.

[2]周婷，李燕，何黎.皮肤美白机制的研究进展[J].皮肤病与性病，2017，39（3）:168-172.

[3]陈小娥，朱文元.皮肤的保湿机制研究进展[J].现代医药卫生，2011，27（18）:2802-2804.

[4]梅华倩，吴震生，王领，等.6种植物提取物组合后的控油抗炎功效研究[J].山东化工，2022，51（5）:66-68.

[5]鞠强，夏隆庆.皮脂腺与痤疮[J].中国医学科学院学报，2007，29（2）:272-274.

[6]鞠强，沈丹蓓，夏隆庆.人皮脂腺细胞与雄激素关系的研究进展[J].国外医学（皮肤性病学分册），2002，28（6）:372-374.

[7]吴巧云，郑敏.皮脂腺功能及调控的研究进展[J].医学综述，2006，12（20）:1217-1219.

[8]王一帆，赖家珍，龙晓英，等.中药美白机制及功效评价进展[J].广东药学院学报，2014（4）:525-529.

[9]王银娟，顾华，郭美华，等.黄褐斑患者皮损及血液中Toll样受体2和4的表达[J].中华皮肤科杂志，2015，48（2）:100-103.

[10]岳学状，朱文元.皮肤的颜色及其测量[J].临床皮肤科杂志，2003，32（9）:554556.

[11]刘婷.熬夜人群皮肤生理特性与皮肤微生态的相关研究[D].上海：上海应用技术大学，2020.

[12]吴艳.油性皮肤和皮脂腺分泌的调控[J].临床皮肤科杂志，2004，33（12）:769-771.

[13]来吉祥，何聪芬，董银卯.皮肤衰老机理和抗衰老化妆品的研究进展[C] //第十一届全国日用化工学术研讨会.北京日化协会，2008.

[14]张春华，张崇志，金鹿，等.生物钟生理功能及影响因素的研究进展[J].畜牧与饲料科学，2021，42（4）:67-73.

[15]郭灵灵.光侵扰对人体节律相移的影响因素及实验研究[D].大连：大连理工大学，2022.

[16]《心肺血管病杂志》编辑部.中国心血管健康与疾病报告2019[J].心肺血管病杂志，2020，39（9）:1145-1156.

[17]俞强.生物钟：基因表达的振荡器[J].中国科学：生命科学，2018，48（3）:343-346.

[18]吴超，杨盛力，赵志辉.生物钟基因NPAS2的研究进展[J].山东医药，2013，53（31）:91-94.

[19]胡晓峰，薛红，宋开源.生物钟基因的一些非生物钟效应研究进展[J].成都医学院学报，2012，7（1）:154-158.

[20]王钧左，陈励，张斌，等.时钟基因Bmal1在昼夜节律行为调节中的研究进展[J].军事医学，2019，43（4）:301-304.

[21]高倩，曹济民.钟基因clock功能的研究进展[J].生理科学进展，2016，47（1）:77-80.

[22]冰寒.听肌肤的话-2-问题肌肤护理全书[M].青岛：青岛出版社，2019.

[23]冰寒.素颜女神：听肌肤的话[M].青岛：青岛出版社，2016.

[24]DRAELOS Z D.药妆品[M].许德田，译.北京：人民卫生出版社，2018.

[25]彭冠杰，郭清泉.美白化妆品科学与技术[M].北京：中国轻工业出版社，2019.

[26] SARKAR R，RANJAN R，GARG S，et al.Periorbital hyperpigmentation:a comprehensive review[J].The Journal of Clinical and Aesthetic Dermatology，2016，9（1）:49-55.

[27] AHMADRAJI F，SHATALEBI M A.Evaluation of the clinical efficacy and safety of an eye counter pad containing caffeine and vitamin K in emulsified Emu oil base[J].Advanced Biomedical Research，2015，4:10.

[28] GALLELLI L.Escin:a review of its anti-edematous，anti-inflammatory，and venotonic properties[J].Drug Design，Development and Therapy，2019，13:3425-3437.

[29] WATANABE F，HASHIZUME E，CHAN G P，et al.Skin-whitening and skin -condition-improving effects of topical oxidized glutathione:a double-blind and placebo-controlled clinical trial in healthy women [J].Clinical，Cosmetic and Investigational Dermatology，2014，7:267-274.

[30] ZHANG F D，LI Y B，ZHANG L M，et al.Synergistic protective effects of escin and low- dose glucocorticoids on blood-retinal barrier breakdown in a rat model of retinal ischemia[J].Molecular Medicine Reports，2013，7（5）:1511-1515.

[31] LUBOV J E，CVAMMEN W，KEMP M G.The impact of the circadian clock on skin physiology and cancer development[J].International Journal of Molecular Sciences，2021，22（11）:6112.

[32] UKAI H，UEDA H R.Systems biology of mammalian circadian clocks[J].Annual Review of Physiology，2010，72:579-603.

[33] WALOCKO F M，EBER A E，KERI J E，et al.The role of nicotinamide in acne treatment[J].Dermatologic Therapy，2017，30（5）.

[34] BISSETT D L，MIYAMOTO K，SUN P，et al.Topical niacinamide reduces yellowing，wrinkling，red blotchiness，and hyperpigmented spots in aging facial skin[J].International Journal of Cosmetic Science，2004，26（5）:231-238.

[35]LEE D J，LEE J，HA J，et al.Defective barrier function in melasma skin[J].Journal of the European Academy Dermatol Venereol，2012，26（12）:1533-1537.

[36] TORRES- ÁLVAREZ B，MESA-GARZA I G，CASTANEDO-CÁZARES J P，et al.Histochemical and immunohistochemical study in melasma:evidence of damage in the basal membrane [J].The American Journal of Dermatopathology，2011，33（3）:291-295.

[37] REGAZZETTI C，DE DONATIS G M，GHORBEL H H，et al.Endothelial cells promote pigmentation through endothelin receptor B activation [J].Journal of Investigative Dermatology，2015，135（12）:3096-3104.

[38] JANG S I，LEE M，HAN J，et al.A study of skin characteristics with long-term sleep restriction in Korean women in their 40 s[J].Skin Research and Technology，2020，26（2）:193-199.

[39] LÉGER D，GAURIAU C，ETZI C，et al.“ You look sleepy …”The impact of sleep restriction on skin parameters and facial appearance of 24 women [J].Sleep Medicine，2022，89:97-103.

[40] SHAO L，JIANG S J，LI Y，et al.Regular late bedtime significantly affects the skin physiological characteristics and skin bacterial microbiome [J].Clinical，Cosmetic and Investigational Dermatology，2022，15:1051-1063.

[41] PIÉRARD- FRANCHIMONT C，PIÉRARD G E，KLIGMAN A.Seasonal modulation of sebum excretion[J].Dermatology，1990，181（1）:21-22.

[42] ZHAO C S，WANG X，MAO Y Q，et al.Variation of biophysical parameters of the skin with age，gender，and lifestyles[J].Journal of Cosmetic Dermatology，2020，20:249-255.

[43] DRAELOS Z D，MATSUBARA A，SMILES K.The effect of 2% niacinamide on facial sebum production[J].Journal of Cosmetic and Laser Therapy，2006，8（2）:96-101.

[44]CHAO S，ZHAO M M，XIN WANG M D，et al.Variation of bilphysical parameters of the skin with age，gender，and lifestyles[J].Comsmetic Dermatology，2020（4）:1-7.

[45] SILVEIRA E J D，NASCIMENTO FILHO C H V，YUJRA V Q，et al.BMAL 1 modulates epidermal healing in a process involving the antioxidative defense mechanism [J].International Journal of Molecular Sciences，2020，21（3）:901.

[46] QIN Bing，DENG Yunlong.Overexpression of circadian clock protein cryptochrome（CRY）1 alleviates sleep deprivation-induced vascular inflammation in a mouse model[J].Immunology Letters，2015，163（1）:76-83.

[47] KANG T H，SANCAR A.Circadian regulation of DNA excision repair:implications for chrono-chemotherapy[J].Cell Cycle，2009，8（11）:1665-1667.

[48] KIM M A，KIM E J，KANG B Y，et al.The effects of sleep deprivation on the biophysical properties of facial skin [J].Journal of Cosmetics，Dermatological Sciences and Applications，2017，7（1）:34-47.

[49] JANG S I，JUNG Y，LEE M，et al.Evaluation of changes in skin characteristics due to the poor quality of sleep caused by smartphone usage [J].Journal of Cosmetic Dermatology，2021，21（4）:1656-1665.

[50] MATSUBARA A，DENG G，GONG L L，et al.Sleep deprivation increases facial skin yellowness[J].Journal of Clinical Medicine，2023，12（2）:615.

[51] LYONS A B，MOY L，MOY R，et al.Circadian rhythm and the skin:a review of the literature[J].The Journal of Clinical and Aesthetic Dermatology，2019，12（9）:42-45.

[52] GUPTA S，HALDAR C，SINGH S.Daily variations in plasma melatonin and melatonin receptor（MT1），PER1 and CRY1 expression in suprachiasmatic nuclei of tropical squirrel，Funambulus pennanti[J].Journal of Comparative Physiology A，2013，199（9）:763-773.

[53] SLOMINSKI A T，HARDELAND R，REITER R J.When the circadian clock meets the melanin pigmentary system[J].Journal of Investigative Dermatology，2015，135（4）:943-945.

[54] CLARK G T，YU Y L，URBAN C A，et al.Circadian control of heparan sulfate levels times phagocytosis of amyloid beta aggregates[J].PLoS Genetics，2022，18（2）:e1009994.

[55] FULTZ N E，BONMASSAR G，SETSOMPOP K，et al.Coupled electrophysiological，hemodynamic，and cerebrospinal fluid oscillations in human sleep [J].Science，2019，366（6465）:628-631.

[56] SUNDELIN T，LEKANDER M，SORJONEN K，et al.Negative effects of restricted sleep on facial appearance and social appeal [J].Royal Society Open Science，2017，4（5）:160918.

[57] CHU C Y，HOLST S C，ELMENHORST E M，et al.Total sleep deprivation increases brain age prediction reversibly in multisite samples of young healthy adults[J].The Journal of Neuroscience:the Official Journal of the Society for Neuroscience，2023，43（12）:2168-2177.

[58] HEPLER C，WEIDEMANN B J，WALDECK N J，et al.Time-restricted feeding mitigates obesity through adipocyte thermogenesis[J].Science，2022，378（6617）:276-284.

[59] SINNER M P，MASURAT F，EWBANK J J，et al.Innate immunity promotes sleep through epidermal antimicrobial peptides[J].Current Biology，2021，31（3）:564-577. e12.

[60] WAHL S，ENGELHARDT M，SCHAUPP P，et al.The inner clock—Blue light sets the human rhythm[J].Journal of Biophotonics，2019，12（12）:e201900102.

[61] ZHENG L H，HAN X，YAO S，et al.The CD8α-PILRαinteraction maintains CD8+T cell quiescence[J].Science，2022，376（6596）:996-1001.

[62] SUN Y，WANG P L，LI H Y，et al.BMAL1 and CLOCK proteins in regulating UVB induced apoptosis and DNA damage responses in human keratinocytes [J].Journal of Cellular Physiology，2018，233（12）:9563-9574.

[63] JANICH P，PASCUAL G，MERLOS-SUÁREZ A，et al.The circadian molecular clock creates epidermal stem cell heterogeneity[J].Nature，2011，480（7376）:209-214.

[64] GEYFMAN M，KUMAR V，LIU Q，et al.Brain and muscle Arnt-like protein -1（BMAL1）controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis[J].Proceedings of the National Academy of Sciences of the United States of America，2012，109（29）:11758-11763.

[65] GAUCHER J，MONTELLIER E，SASSONE-CORSI P.Molecular cogs:interplay between circadian clock and cell cycle[J].Trends in Cell Biology，2018，28（5）:368379.

[66] LANDZBERG D，TROTTI L M.Is idiopathic hypersomnia a circadian rhythm disorder?[J].Current Sleep Medicine Reports，2019，5（4）:201-206.

[67] HIRSHKOWITZ M，WHITON K，ALBERT S M，et al.National sleep foundation’ s sleep time duration recommendations:methodology and results summary[J].Sleep Health，2015，1（1）:40-43.

[68] LEE S.Naturally occurring consecutive sleep loss and day-to-day trajectories of affective and physical well-being[J].Annols of Behavioral Medicine，2022，56（4）:393-404.

[69] TAYLOR B J，MATTHEWS K A，HASLER B P，et al.Bedtime variability and metabolic health in midlife women:the SWAN sleep study[J].Sleep，2016，39（2）:457-465.

[70] YANG Q H，DURMER J L，WHEATON A G，et al.Sleep duration and excess heart age among US adults[J].Sleep Health，2018，4（5）:448-455.

[71] FAUST L，FELDMAN K，MATTINGLY S M，et al.Deviations from normal bedtimes are associated with short-term increases in resting heart rate[J].NPJ Digital Medicine，2020，3（1）:39.

[72] MCALPINE C S，KISS M G，RATTIK S，et al.Sleep modulates haematopoiesis and protects against atherosclerosis[J].Nature，2019，566（7744）:383-387.

[73] LÜSCHER T F.Novel cardiovascular risk factors:air pollution，air temperature，pain，and sleep duration[J].European Heart Journal，2019，40（20）:1577-1580.

[74] ALLADA R，BASS J.Circadian mechanisms in medicine [J].The New England Journal of Medicine，2021，384（6）:550-561.

[75] STANGHERLIN A，WATSON J L，WONG D C S，et al.Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology [J].Nature Communications，2021，12（1）:1-14.

[76] SPIEGEL K，LEPROULT R，L’ HERMITE-BAL'RIAUX M，et al.Leptin levels are dependent on sleep duration:relationships with sympathovagal balance，carbohydrate regulation，cortisol，and thyrotropin [J].The Journal of Clinical Endocrinology&Metabolism，2004，89（11）:5762-5771.

[77] HARDMAN J A，TOBIN D J，HASLAM I S，et al.The peripheral clock regulates human pigmentation[J].Journal of Investigative Dermatology，2015，135（4）:1053-1064.

[78] YOSIPOVITCH G，XIONG G L，HAUS E，et al.Time-dependent variations of the skin barrier function in humans:transepidermal water loss，stratum corneum hydration，skin surface pH，and skin temperature[J].Journal of Investigative Dermatology，1998，110（1）:20-23.

[79] MATSUNAGA N，ITCHO K，HAMAMURA K，et al.24- hour rhythm of aquaporin -3 function in the epidermis is regulated by molecular clocks [J].Journal of Investigative Dermatology，2014，134（6）:1636-1644.

[80] MOHD AZMI N A S，JULIANA N，AZMANI S，et al.Cortisol on circadian rhythm and its effect on cardiovascular system [J].International Journal of Environmental Research and Public Health，2021，18（2）:676.

[81] PLIKUS M V，VAN SPYK E N，PHAM K，et al.The circadian clock in skin:implications for adult stem cells，tissue regeneration，cancer，aging，and immunity [J].Journal of Biological Rhythms，2015，30（3）:163-182.

[82]HENRY F，ARRESE J E，CLAESSENS N，et al.La peau et son horloge chronobiologique au quotidien Revue M'dicale de Liège[J].2002，57（10）:661-665.

[83] MATSUI M S，PELLE E，DONG K，et al.Biological rhythms in the skin[J].International Journal of Molecular Sciences，2016，17（6）:801.

[84] NIKBAKHTIAN S，REED A B，OBIKA B D，et al.Accelerometer-derived sleep onset timing and cardiovascular disease incidence:a UK Biobank cohort study [J].European Heart Journal- Digital Health，2021，2（4）:658-666.

[85] POURCET B，DUEZ H.Circadian control of inflammasome pathways:implications for circadian medicine[J].Frontiers in Immunology，2020，11:1630.

[86] WU T Q，MEI Shuqing，ZHANG Jinxin，et al.Prevalence and risk factors of facial acne vulgaris among Chinese adolescents[J].International Journal of Adolescent Medicine and Health，2007，19（4）:407-412.

[87] JOO J H，HONG I K，KIM N K，et al. Trichosanthes kirilowii extract enhances repair of UVB radiation-induced DNA damage by regulating BMAL1 and miR -142-3p in human keratinocytes[J].Molecular Medicine Reports，2018，17（1）:877-883.

[88] SPÖRL F，SCHELLENBERG K，BLATT T，et al.A circadian clock in HaCaT keratinocytes[J].Journal of Investigative Dermatology，2011，131（2）:338-348.

[89] DIBNER C，SCHIBLER U，ALBRECHT U.The mammalian circadian timing system:organization and coordination of central and peripheral clocks [J].Annual Review of Physiology，2010，72:517-549.

[90] MILLER H E.Colloidal sulphur in dermatology[J].Archives of Dermatology，1935，31（4）:516-525.

[91] BESEDOVSKY L，LANGE T，HAACK M.The sleep-immune crosstalk in health and disease[J].Physiological Reviews，2019，99（3）:1325-1380.

[92] YAN B，LI R H，LI J M，et al.Sleep timing may predict congestive heart failure:a community-based cohort study[J].Journal of the American Heart Association，2021，10（6）:e018385.

[93] ACKERMANN K，REVELL V L，LAO O，et al.Diurnal rhythms in blood cell populations and the effect of acute sleep deprivation in healthy young men[J].Sleep，2012，35（7）:933-940.

[94] INGEBORG F，RINGHEIM E K E，ERIK E K，et al.The association between self-reported sleep problems，infection，and antibiotic use in patients in general practice[J].Frontiers in Psychiatry，2023，14:1033034.

[95] LIEW S C，AUNG T.Sleep deprivation and its association with diseases -a review[J].Sleep Medicine，2021，77:192-204.

[96] FANG Yu，FORGER D B，FRANK E，et al.Day-to-day variability in sleep parameters and depression risk:a prospective cohort study of training physicians [J].NPJ Digital Medicine，2021，4（1）:1-9.

[97] EVERSON C A，HENCHEN C J，SZABO A，et al.Cell injury and repair resulting from sleep loss and sleep recovery in laboratory rats[J].Sleep，2014，37（12）:1929-1940.

[98] VACCARO A，KAPLAN DOR Y，NAMBARA K，et al.Sleep loss can cause death through accumulation of reactive oxygen species in the gut[J].Cell，2020，181（6）:1307-1328.

[99] CARROLL J E，PRATHER A A.Sleep and biological aging:a short review[J].Current Opinion in Endocrine and Metabolic Research，2021，18:159-164.

[100] BUYSSE D J.Sleep health:can we define it?does it matter? [J].Sleep，2014，37（1）:9-17.

[101] DUAN J Y，GREENBERG E N，KARRI S S，et al.The circadian clock and diseases of the skin[J].FEBS Letters，2021，595（19）:2413-2436.

[102] GOOLEY J J.How much day-to-day variability in sleep timing is unhealthy? [J].Sleep，2016，39（2）:269-270.

[103] KAHAN V，ANDERSEN M L，TOMIMORI J，et al.Can poor sleep affect skin integrity?[J].Medical Hypotheses，2010，75（6）:535-537.

[104] PANEL C C，WATSON N F，BADR M S，et al.Recommended amount of sleep for a healthy adult:a joint consensus statement of the American academy of sleep medicine and sleep research society[J].Sleep，2015，38（6）:843-844.

[105] DEPNER C M，MELANSON E L，ECKEL R H，et al.Ad libitum weekend recovery sleep fails to prevent metabolic dysregulation during a repeating pattern of insufficient sleep and weekend recovery sleep[J].Current Biology，2019，29（6）:957-967.

[106] ALKHALAF M I.Chemical composition，antioxidant，anti-inflammatory and cytotoxic effects of Chondrus crispus species of red algae collected from the Red Sea along the Shores of Jeddah city[J].Journal of King Saud University- Science，2021，33（1）:101210.

[107] CHAPUT J P，DUTIL C，FEATHERSTONE R，et al.Sleep timing，sleep consistency，and health in adults:a systematic review[J].Applied Physiology，Nutrition，and Metabolism=Physiologie Appliquee，Nutrition et Metabolisme，2020，45（10（Suppl.2））:S232-S247.

[108] HENRY A L，KYLE S D，BHANDARI S，et al.Measurement，classification and evaluation of sleep disturbance in psoriasis:a systematic review [J].PLoS One，2016，11（6）:e0157843.

[109] SHIN S Y，LEE D H，GIL H N，et al.Agerarin，identified from Ageratum houstonianum，stimulates circadian CLOCK-mediated aquaporin-3 gene expression in HaCaT keratinocytes[J].Scientific Reports，2017，7（1）:1-13.

[110] RAY S，VALEKUNJA U K，STANGHERLIN A，et al.Circadian rhythms in the absence of the clock gene Bmal1[J].Science，2020，367（6479）:800-806.

[111] ZHANG C Z，SUN H Z，ZHANG C H，et al.Effects of photoperiod on circadian clock genes in skin contribute to the regulation of hair follicle cycling of Inner Mongolia white Cashmere goats[J].Animal Science Journal，2020，91（1）:e13320.

[112] KIMMEY J M.Immunity，infection，and the zebrafish clock[J].Infection and Immunity，2022，90（9）:e0058821.

[113] WATTS L M，BROWNE J A，MURPHY B A.Investigation of a non-invasive method of assessing the equine circadian clock using hair follicle cells [J].Journal of Circadian Rhythms，2012，10:7.

[114] TANIOKA M，YAMADA H，DOI M，et al.Molecular clocks in mouse skin[J].Journal of Investigative Dermatology，2009，129（5）:1225-1231.

[115] COX K H，TAKAHASHI J S.Circadian clock genes and the transcriptional architecture of the clock mechanism[J].Journal of Molecular Endocrinology，2019，63（4）:R93-R102.

[116] YEOM M，LEE H，SHIN S，et al.PER，a circadian clock component，mediates the suppression of MMP-1 expression in HaCaT keratinocytes by cAMP[J].Molecules，2018，23（4）:745.

[117] THORBURN P T，RIHA R L.Skin disorders and sleep in adults:where is the evidence?[J].Sleep Medicine Reviews，2010，14（6）:351-358.

[118] WANG H，VAN SPYK E，LIU Q，et al.Time-restricted feeding shifts the skin circadian clock and alters UVB-induced DNA damage[J].Cell Reports，2017，20（5）:1061-1072.

[119] WANG C S，HU B，RANGARAJAN S，et al.Association of bedtime with mortality and major cardiovascular events:an analysis of112，198 individuals from 21 countries in the PURE study[J].Sleep Medicine，2021，80:265-272.

[120] GANCEVICIENE R，GRAZIENE V，FIMMEL S，et al.Involvement of the corticotropin- releasing hormone system in the pathogenesis of acne vulgaris [J].British Journal of Dermatology，2009，160（2）:345-352.

[121] DESOTELLE J A，WILKING M J，AHMAD N.The circadian control of skin and cutaneous photodamage[J].Photochemistry and Photobiology，2012，88（5）:1037-1047.